penicillic acid :
| 2: Vet Res Commun 2001 Apr;25(3):205-23 |
|
Experimental mycotoxic nephropathy in pigs provoked by a
diet containing ochratoxin A and penicillic acid.
Stoev SD, Vitanov S, Anguelov G, Petkova-Bocharova T, Creppy EE.
Department of Pathology, Faculty of Veterinary Medicine, Thracian University,
Stara Zagora, Bulgaria.
Mycotoxic nephropathy was induced in 18 young pigs by diets contaminated with
strains of Aspergillus ochraceus containing ochratoxin A (OTA) and penicillic
acid (PA) at levels corresponding to those naturally encountered in animal feeds
in Bulgaria. Haematological and biochemical parameters, as well as the
morphological and ultrastructural changes in various internal organs, and
especially in the kidneys, were examined at different stages of development of
the disease. A mottled surface of the kidneys was only seen in pigs exposed to a
mouldy diet containing 180 ppb OTA for 3 months, but microscopic lesions, as
well as changes in various haematological and biochemical parameters, were
observed in all groups exposed to the same mouldy diet containing only 90 or 180
ppb OTA. Histological examination showed two types of change: degenerative
changes affecting the epithelial cells of the proximal tubules, which
predominated at the initial stage, and proliferative changes in the interstitium,
which predominated at the later stage of the disease. Telangiectasis and lymph
stasis were also seen, as well as degenerative changes in the capillary
endothelium. The characteristic renal lesions were similar to those observed in
spontaneous cases of mycotoxic porcine nephropathy in Bulgaria, but they were a
little different from the classic Danish porcine nephropathy. The enhanced
toxicity of OTA in our study may be due to a synergistic effect between OTA and
PA or to some other unknown metabolites produced by the same ochratoxinogenic
strains of A. ochraceus.
PMID: 11334150
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